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AUG 16, 2026 · JOURNAL ARTICLE

Delivering the blueprint: Advances and challenges in mRNA therapeutics for the respiratory system.

International Journal of Pharmaceutics: X

This is a systematic review article synthesizing mechanisms, delivery methods, challenges, and safety considerations for mRNA-LNP therapeutics in pulmonary disorders, providing expert assessment of the field rather than reporting original trial data.

Expert GuidanceFangru Jia Respiratory Diseases Mrna Therapeutics

Reported

Delivery efficiency to ATII cells…approximately 30%

Lung selectivity of second-genera…∼95%

Ionizable lipid pKa range for air…6.2–6.8

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