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Researcher

Zhaohui Jin

Sichuan University

1 development in the corpus

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AUG 10, 2026 · JOURNAL ARTICLE

Single-cell multiomics identifies an ALDH9A1–carnitine signaling axis driving resistance of NSCLC to immunotherapy

Proceedings of the National Academy of Sciences

Mechanistic discovery in preclinical models with supporting human correlative data, but lacks clinical trial evidence of efficacy in patients with immunotherapy resistance.

PromisingHailei Du Chao Qu Ling Chen

Study details

DesignPreclinical mechanistic study with correlat…

InterventionALDH9A1 genetic loss, pharmacological ALDH9…

ComparatorWild-type or control-treated mice; anti-PD-…

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