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Zain Ali Burney

Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.

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AUG 7, 2026 · JOURNAL ARTICLE

Limited duration of dexamethasone in newly diagnosed AL amyloidosis: impact on response, toxicity, and survival.

Annals of Medicine

Retrospective cohort study of 216 newly diagnosed AL amyloidosis patients demonstrating that limited dexamethasone (≤3 months) achieves similar overall response rates with faster deep hematologic response and reduced toxicity compared to prolonged exposure, with multivariable adjustment for confounding.

Strong EvidenceHong Li Ryan Brown Antibodies, Monoclonal

Reported

Sample size216

VGPR or better at 6 months (limit…77.5% vs 56.5%

p-value for VGPR comparison0.001

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