SEP 4, 2026 · JOURNAL ARTICLE
Restoration of tumor vascular integrity by P188 improves chemotherapy and immunotherapy efficacy in triple negative breast cancer
Biomedicine & Pharmacotherapy
A sound preclinical study combining in vitro and in vivo work in a mouse TNBC model, demonstrating mechanistic plausibility and efficacy enhancement, but lacking human data, clinical endpoints, or direct comparison to standard anti-angiogenic therapy.
Reported
Key mechanism: tight junction pro…Increased Zonula occludens-1 (ZO-1) express…
Vascular perfusion markerSignificantly enhanced Dextran delivery
Tumor progression with combinatio…Significantly suppressed