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Ronald B. Tjalkens

Barrow Neurological Institute

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AUG 12, 2026 · JOURNAL ARTICLE

Infection with Western equine encephalitis virus causes severe regional glial reactivity and neurodegeneration in the hippocampus with progressive accumulation of amyloid-β

Journal of Neuropathology & Experimental Neurology

Mechanistic, observational study in an animal model describing temporal pathological changes after viral infection; raises questions about WEEV-related neurodegeneration but does not test clinical outcomes or establish causation of neurodegenerative disease.

Hypothesis-GeneratingMegan R. Hager Omar Yanouri Savannah M. Rocha

Reported

Time points assessed1, 2, and 4 weeks postinfection

Peak gliosis timing1-week postinfection

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