SEP 2, 2026 · JOURNAL ARTICLE
Omega-3 polyunsaturated fatty acids and epigallocatechin-3-gallate attenuate obesity-associated CD44-high stemness in colorectal cancer through modulation of Notch1, Wnt/β-catenin and PI3K/mTOR signaling
Biomedicine & Pharmacotherapy
This is an in vitro organoid study without clinical outcomes, animal models, or randomized comparison; it demonstrates mechanistic effects of a nutrient combination on signaling pathways in patient-derived tissue but lacks evidence of efficacy in humans or disease prevention.
Reported
Study population sourcePatient-derived organoids from normal mucos…
EPA:DHA ratio1:1
Primary molecular endpointCD44 and HES1 expression; Wnt target genes;…